Gabapentin (Neurontin) for the Remedy of Hyperemesis Gravidarum

Whereas nearly all of pregnant girls expertise nausea and/or vomiting throughout the first trimester of being pregnant, a smaller subset of girls — round 1% — expertise extra extreme and intractable vomiting, or hyperemesis gravidarum (HG).  If left untreated, extended hyperemesis can result in weight reduction, dehydration, nutrient deficiencies and electrolyte disturbances.  Hyperemesis may additionally enhance danger for anxiousness or despair throughout being pregnant.

We’ve few choices for the efficient remedy for hyperemesis gravidarum. Ondansetron (Zofran) is usually used on this setting, and a pilot examine indicated that the antidepressant mirtazapine (Remeron) may additionally be useful for the remedy of HG. Based on a small examine introduced at this 12 months’s American Faculty of Obstetrics and Gynecology Annual Medical and Scientific Assembly, gabapentin could also be an alternative choice for the remedy of hyperemesis gravidarum.  

This examine recruited pregnant girls with hyperemesis gravidarum who had vailed to answer earlier remedies had been randomized to obtain gabapentin (1,800 to 2,400 mg per day) or an lively comparator, both ondansetron or metoclopramide, for 7 days.  All medicines had been administered orally. Signs had been assessed utilizing the Motherisk pregnancy-unique quantification of nausea and emesis (PUQE) questionnaire.

A complete of 31 girls had been randomized to remedy; 21 members (12 gabapentin and 9 controls) supplied analyzable information.  The researchers noticed that ladies within the gabapentin group had better reductions in PUQE scores and better will increase in oral vitamin in comparison with girls receiving the lively comparator.  As well as, girls within the gabapentin teams had larger world satisfaction with and aid from the remedy, and thus had been extra more likely to request continuation of remedy with gabapentin.

That is clearly a small examine and would require replication in a bigger randomized trial; nevertheless, the information is promising.  One of many important challenges in treating hyperemesis is that remedy is usually delivered throughout the first trimester, and thus, with any intervention, there are considerations concerning danger of congenital malformations.  Knowledge concerning the usage of gabapentin throughout being pregnant has grown significantly, with a current examine together with over 4000 first trimester exposures indicating no proof of an affiliation between gabapentin publicity throughout early being pregnant and total danger of main malformations


Ruta Nonacs, MD PhD


Small examine finds gabapentin successfully treats hyperemesis gravidarum (Healio)


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