Important Reads: SSRI Antidepressants Do Not Improve Danger of Miscarriage

Many ladies ask whether or not taking antidepressants might improve the danger for miscarriage or spontaneous abortion.  Some, however not all, research have demonstrated an elevated danger of miscarriage amongst ladies who use antidepressants. Nonetheless, it has been tough to find out whether or not this elevated danger noticed in early research is expounded to publicity to the remedy itself, or whether or not elevated danger could also be attributable  to publicity to different danger components, together with maternal despair. Many of those research the place to in a position to separate these two potentialities, as they in contrast charges of miscarriage in ladies taking antidepressants to charges in wholesome ladies with no hitory of despair.  

A meta-analysis printed in JAMA Psychiatry analyzed knowledge from a complete of 11 research assessing being pregnant outcomes in ladies taking antidepressant drugs throughout being pregnant.  This meta-analysis, the most important thus far, demonstrated no important affiliation between antidepressant publicity and danger for spontaneous abortion (odds ratio [OR], 1.47; 95% CI, 0.99 to 2.17; P = .055).

Newer research have tried to supply extra correct estimates of the prevalence of miscarriage whereas making an allowance for potential confounding components.  

In a single research, Kjaersgaard and colleagues examined being pregnant outcomes in over a million pregnancies included within the Danish Medical Beginning Registry and the Danish Nationwide Hospital Registry.  Knowledge have been assessed for 1,005,319 pregnancies, of which 114,721 (11.4%) resulted in a spontaneous abortion.   The authors discovered a barely elevated danger of spontaneous abortion related to the usage of antidepressants: 12.0% in ladies with antidepressant publicity versus 11.1% in ladies with no publicity.  Nonetheless, trying solely at ladies with a analysis of despair, the adjusted danger ratio (RR) for spontaneous abortion after any antidepressant publicity was 1.00 (95% CI 0.80-1.24). Thus, the researchers concluded {that a} analysis of despair – however not publicity to antidepressant – is related to a barely larger danger of miscarriage.

These two figures are a pleasant depiction of the findings.  Determine 1 (one the left) reveals the unadjusted danger ratios (RR) for spontaneous abortion after publicity to particular antidepressants in comparison with the unexposed controls.  Determine 2 (on the appropriate) reveals the nadjusted RRs for spontaneous abortions after publicity to particular antidepressants amongst ladies with a analysis of despair, evaluating ladies with and with out prenatal antidepressant publicity. At the very least for the SSRIs, these findings point out no improve in danger related to antidepressant publicity.



In unadjusted analyses, much less generally used antidepressants, comparable to mirtazapine, venlafaxine, and duloxetine, have been related to spontaneous abortions amongst ladies with despair.  Nonetheless, the variety of ladies on these drugs was a lot smaller, making the precision of those findings extra questionable.  Moreover, it’s attainable that sufferers on these drugs had extra extreme or remedy resistant despair, contemplating SSRIs are sometimes thought of first-line antidepressants to be used in being pregnant.

One other research from Andersen and colleagues recognized all registered pregnancies in Denmark from 1997 to 2010, utilizing the Medical Beginning Registry, and all data and the Nationwide Hospital Register. Knowledge on SSRI use was gathered utilizing the Nationwide Prescription Register. The researchers recognized 1,279,840 pregnancies (911,569 births, 142,093 miscarriages, and 226,178 induced abortions).

Of the 22,884 uncovered to an SSRI in the course of the first 35 days of being pregnant, 12.6% (2,883) resulted in miscarriage in contrast with 11.1% amongst those that discontinued SSRI remedy. The adjusted odds ratio (OR) of getting a miscarriage after publicity to an SSRI was 1.27 (95% confidence interval [CI] 1.22-1.33) in contrast with unexposed. Nonetheless, once they checked out ladies who discontinued SSRI remedy 3-12 months earlier than being pregnant, they discovered that this group additionally had an elevated danger of getting a miscarriage in comparison with unexposed ladies (OR=1.24, 95% CI 1.18-1.30).  Thus, they concluded that having a analysis of despair, relatively than use of an antidepressant, will increase danger for miscarriage.  

Based mostly on these findings, we will conclude that for ladies taking SSRI antidepressants previous to being pregnant, stopping or truly fizzling out the antidepressant doesn’t appreciably have an effect on their danger of miscarriage. Whie the info is much less clear relating to danger in ladies taking SNRIs and mirtazapine, it seems that the influence of those drugs on danger for miscarriage could be very small.  Nonetheless, we do know that stopping antidepressants throughout being pregnant considerably will increase the danger of depressive relapse.  

Ruta Nonacs, MD PhD


Andersen JT, Andersen NL, Horwitz H, Poulsen HE, Jimenez-Solem E. Publicity to Selective Serotonin Reuptake Inhibitors in Early Being pregnant and the Danger of Miscarriage.  Obstet Gynecol. 2014 Sep 5.

Johansen RL, Mortensen LH, Andersen AM, Hansen AV, Strandberg-Larsen Okay.  Maternal use of selective serotonin reuptake inhibitors and danger of miscarriage – assessing potential biases.  Paediatr Perinat Epidemiol. 2015 Jan;29(1):72-81. 

Kjaersgaard MI, Parner ET, Vestergaard M, et al.  Prenatal antidepressant publicity and danger of spontaneous abortion – a population-based research.  PLoS One. 2013 Aug 28; 8(8):e72095.

Ross LE, Grigoriadis S, Mamisashvili L, et al. Chosen Being pregnant and Supply Outcomes After Publicity to Antidepressant Treatment:  A Systematic Overview and Meta-analysis.  JAMA Psychiatry 2013;70(4):436-443.


Associated Posts:

Girls Who Cease SSRIs Previous to Being pregnant Have Similar Danger of Miscarriage as Girls who Elect to Stay on SSRI Antidepressants

Use of Antidepressants Does Not Improve the Danger of Miscarriage


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