Is St. John’s Wort Efficient for PMDD?

St. John’s wort (Hypericum perforatum) is an natural preparation which has been proven, in some research, to be efficient for the remedy of gentle to average depressive signs. St. John’s wort is now one of the vital generally used natural merchandise in america and is broadly utilized in Europe.

We don’t know precisely what’s answerable for the antidepressant results of St. John’s wort; nevertheless, it seems that St. John’s wort could enhance ranges of serotonin within the mind, which is what typical antidepressants, together with the selective serotonin reuptake inhibitors or SSRIs, do.  

For the remedy of premenstrual dysphoric dysfunction or PMDD, SSRIs are the first-line pharmacological brokers and are extremely efficient.  So it’s potential that St. John’s wort, which can additionally modulate serotonin ranges within the mind, may additionally be efficient for the remedy of premenstrual signs.  Nevertheless, is there any knowledge to assist its effectiveness on this setting?

A number of research have assessed the effectiveness of St. John’s wort, for the remedy of premenstrual signs.  A complete of 4 research checked out St. John’s wort; nevertheless, most of those research examined the medication in ladies with premenstrual syndrome (PMS) relatively than PMDD. 

Two of the research indicated that St. John’s wort was superior to placebo for the remedy of bodily signs however didn’t have a big impression on depressive signs, anxiousness or irritability. One of many research reported an analogous pattern however the findings weren’t statistically vital.  Ryoo and colleagues reported that St. John’s wort improved premenstrual signs of emotional lability, hostility or anger, and impulsivity, however didn’t differ from placebo by way of its impression on depressive signs, anxiousness, vitality degree, ache and different bodily signs.

So the jury remains to be out.  

That mentioned, many ladies who current with PMDD aren’t keen on utilizing SSRI and SNRI antidepressants for the remedy of their signs.  Typically this resistance is expounded to the stigma of taking psychiatric drugs; different occasions the choice displays considerations about negative effects, akin to weight achieve or sexual dysfunction.  

Based mostly on the info we now have, one may take into account a trial of St. John’s wort  in a girl with PMDD.  It is very important be aware that whereas St. John’s wort is a “pure” treatment, it’s getting used as a drugs and has negative effects, in addition to drug interplay.  Some phrases of Warning:

Aspect Results: St. John’s wort could trigger insomnia, vivid desires, anxiousness, irritability, abdomen upset, and diarrhea.  St. John’s wort can be related to photosensitivity and pores and skin rash.

Threat of hypomania and mania:  The literature a number of case studies of hypomania and hypomania in people with bipolar dysfunction handled with Saint John’s wort.

Contraception: St. John’s wort decreases the effectiveness of hormonal contraceptives, together with contraceptive implants and oral contraceptive tablets.  This can lead to unintended being pregnant, in addition to breakthrough bleeding.  

Use throughout being pregnant: Presently there is no such thing as a knowledge concerning using SJW throughout being pregnant. Due to this fact, using efficient contraception is really helpful in ladies of reproductive age. 


Ruta Nonacs, MD PhD


Learn Extra: 

Jang SH, Kim DI, Choi MS.  Results and remedy strategies of acupuncture and natural drugs for premenstrual syndrome/premenstrual dysphoric dysfunction: systematic overview.  BMC Complement Altern Med. 2014 Jan 10;14:11. Free Article. 

Ryoo JG, Chun SL, Lee YJ, Suh SH.  The Results of St. John’s wort on Premenstrual Syndrome in Single Girls: A Randomized Double-Blind, Placebo-Managed Research.  Scientific Psychopharmacology and Neuroscience 2010; 8(1): 30-37 

Leave a Reply

Your email address will not be published. Required fields are marked *